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Microalbuminuria in patients with Type 2 diabetes mellitus from general practice: course and predictive value
Author(s) -
De Grauw W. J. C.,
Van De Lisdonk E. H.,
Van Gerwen W. H. E. M.,
Verstappen M.,
Van Den Hoogen H. J. M.,
Willems J. L.,
Van Weel C.
Publication year - 2001
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2001.00423.x
Subject(s) - medicine , microalbuminuria , predictive value , diabetes mellitus , type 2 diabetes mellitus , value (mathematics) , intensive care medicine , endocrinology , statistics , mathematics
SUMMARYAims To assess the course of microalbuminuria in patients with Type 2 diabetes mellitus in general practice and the predictive value of urinary albumin concentration on all‐cause mortality, cardiovascular mortality and cardiovascular morbidity. Methods Cohort study in Type 2 diabetic patients tested for microalbuminuria in 1992, and re‐tested in 1998. During follow‐up all cardiovascular morbidity and mortality were recorded. Results Of the original sample of 317 patients, 163 patients were re‐tested. The mean change in urinary albumin concentration was +16.2 mg/l (range −122.0 to +602 mg/l). Seventy‐five per cent of the patients without microalbuminuria in 1992 still had no microalbuminuria in 1998 and 40% of those with microalbuminuria in 1992 reverted to normoalbuminuria in 1998. Cox survival analysis, stratified for age, showed that microalbuminuria at baseline resulted in a risk ratio of all‐cause mortality of 1.4 (95% confidence interval 0.8–2.7), of cardiovascular mortality of 1.2 (0.5–2.8) and of new cardiovascular events (including cardiovascular mortality) of 1.4 (0.8–2.3). Conclusions In the majority of patients the change of urinary albumin excretion was small, but the range was wide. A weak non‐significant relationship between microalbuminuria and all‐cause mortality and cardiovascular morbidity was observed.