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Gastric parietal cell antibodies are associated with glutamic acid decarboxylase‐65 antibodies and the HLA DQA1*0501‐DQB1*0301 haplotype in Type 1 diabetes mellitus
Author(s) -
De Block C. E. M.,
De Leeuw I. H.,
Rooman R. P. A.,
Winnock F.,
Du Caju M. V. L.,
Van Gaal L. F.,
Registry The Belgian Diabetes
Publication year - 2000
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2000.00354.x
Subject(s) - medicine , autoantibody , gastroenterology , diabetes mellitus , anti thyroid autoantibodies , antibody , autoimmunity , type 1 diabetes , glutamate decarboxylase , immunology , thyroid peroxidase , endocrinology , biochemistry , chemistry , enzyme
SUMMARYAims To assess the prevalence of thyrogastric autoimmunity in relation to age, sex, β‐cell antibody status and HLA DQ haplotypes in Type 1 diabetes mellitus. Methods One hundred and seventy‐one patients with Type 1 diabetes mellitus were studied (male/female 86/85; mean age 19 ± 11 years; duration of diabetes 5 ± 4 years). Islet cell antibodies (ICA) and parietal cell antibodies (PCA) were measured using indirect immunofluorescence; glutamic acid decarboxylase‐65 antibodies (GADA) by radiobinding assay and thyroid peroxidase antibodies (TPO) with an immunoradiometric assay (IRMA). Results The majority of subjects (81.3%) showed one or more autoantibodies. The prevalence rates were: GADA 64.9%, ICA 46.2%, PCA 19.9% and TPO 19.3%. Patients with ICA+ ≥ 3 years after diagnosis had a higher prevalence of GADA ( P = 0.03, odds ratio (OR) 2.66) and thyrogastric antibodies ( P = 0.05, OR 2.23) than subjects ICA– after 3 years. PCA+ patients were older ( P = 0.04), had a higher prevalence of GADA ( P = 0.005, OR 3.89) and TPO ( P = 0.05, OR 2.50) than PCA– subjects. Logistic regression analysis showed that PCA status was determined by the HLA DQA1*0501‐DQB1*0301 haplotype (β = 2.94, P = 0.04) and GADA status (β = 2.44, P = 0.041). Conclusions Thyrogastric antibodies are highly prevalent in Type 1 diabetes mellitus, especially in patients with persisting ICA. Screening for gastric autoimmunity is particularly advised in patients who are positive for GADA and for the HLA DQA1*0501‐DQB1*0301 haplotype.