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Increased left ventricular mass index and nocturnal systolic blood pressure in patients with Type 2 diabetes mellitus and microalbuminuria
Author(s) -
Rutter M. K.,
McComb J. M.,
Forster J.,
Brady S.,
Marshall S. M.
Publication year - 2000
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2000.00262.x
Subject(s) - microalbuminuria , medicine , blood pressure , left ventricular hypertrophy , ambulatory blood pressure , cardiology , body mass index , diabetes mellitus , type 2 diabetes mellitus , diastole , type 2 diabetes , endocrinology
Aims To compare left ventricular mass (LVM) index and function in patients with Type 2 diabetes mellitus with and without microalbuminuria and to investigate the clinical determinants of left ventricular hypertrophy. Methods Echocardiography, electrocardiography and 24‐h ambulatory blood pressure monitoring were performed in microalbuminuric ( n = 29) and normoalbuminuric ( n = 29) patients with Type 2 diabetes and no clinical evidence of heart disease. Groups were individually matched for age, sex and diabetes duration and smoking status. Results LVM index (62 (34–87) vs. 52 (33–89) g/m 2.7 , P = 0.04) and LVH prevalence, using two out of three definitions, were greater in patients with microalbuminuria (LVM/height 2.7 : 72 vs. 59%, P = 0.27, LVM/height: 66 vs. 38%, P = 0.04, LVM/body surface area: 59 vs. 31%, P = 0.03). Night‐time systolic blood pressure (126 (99–163) vs. 120 (104–157) mmHg, P = 0.005) and the night/day systolic blood pressure ratio (0.92 (0.08) vs. 0.88 (0.06), P = 0.04) were higher in those with microalbuminuria. Systolic and diastolic function were similar in both groups. Linear regression analyses showed that body mass index (BMI) was significantly related to log e LVM index ( R 2 = 11.8%, P = 0.005) and a relationship with night/day systolic blood pressure was also suggested ( R 2 = 4.6%, P = 0.057). Conclusions In patients with Type 2 diabetes, LVH is more common and severe in those with microalbuminuria. Its presence may be related to raised night/day systolic blood pressure ratio and is significantly related to BMI. The high prevalence of LVH strengthens the case for echocardiographic screening in Type 2 diabetes to identify high risk patients who might benefit from aggressive cardiovascular risk factor intervention.