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Effects of the new oral hypoglycaemic agent nateglinide on insulin secretion in Type 2 diabetes mellitus
Author(s) -
Whitelaw D. C.,
Clark P. M.,
Smith J. M.,
Nattrass M.
Publication year - 2000
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2000.00256.x
Subject(s) - nateglinide , medicine , proinsulin , insulin , endocrinology , diabetes mellitus , type 2 diabetes , type 2 diabetes mellitus , placebo , alternative medicine , pathology
Summary Aims The new non‐sulphonylurea oral hypoglycaemic agent nateglinide has been shown to enhance insulin secretion in animals and in healthy human volunteers and thus offers a potential advance in the treatment of Type 2 diabetes mellitus. This study examined whether nateglinide can enhance insulin secretion, and particularly the first phase insulin response, in patients with Type 2 diabetes. Methods A double‐blind, placebo‐controlled trial, examining the effects of a single oral dose of 60 mg nateglinide, given 20 min prior to an intravenous glucose tolerance test (IGTT), on insulin secretion in 10 otherwise healthy Caucasian men with recently diagnosed Type 2 diabetes (duration since diagnosis 0–44 months). Results Insulin secretion (both overall and first phase) was significantly increased by nateglinide ( P < 0.001), as were C‐peptide ( P < 0.001) and proinsulin ( P < 0.001) secretion. Overall glucose concentrations following glucose challenge were lower after nateglinide than after placebo ( P = 0.05). Conclusions Nateglinide significantly increases insulin secretion in Type 2 diabetic patients, in particular restoring the first phase insulin response. Further study is necessary to determine the effects of chronic administration on insulin secretion and blood glucose concentration.