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Ions, genes and insulin release: from basic science to clinical disease Based on the 1998 R. D. Lawrence Lecture
Author(s) -
Dunne M. J.
Publication year - 2000
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2000.00247.x
Subject(s) - medicine , insulin , context (archaeology) , ion channel , endocrinology , disease , hyperinsulinism , neuroscience , bioinformatics , insulin resistance , biology , receptor , paleontology
Summary In 1968, reports of the first microelectrode recordings of insulin‐secreting cells were published. Thirty years later it is now established that electrical responses of β‐cells play a critical role in stimulus‐secretion coupling. It is now also clear that defects in ion channel genes compromise the mechanisms which govern secretion and lead to the onset of disease. Here, the physiology of insulin release is reviewed in the context of ion channels, the ionic control of insulin release and the pathophysiology of hyperinsulinism of infancy.