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Comparison of vasodilator effects of substance P in human forearm vessels of normoalbuminuric Type 1 diabetic and non‐diabetic subjects
Author(s) -
Meeking D. R.,
Allard S.,
Munday J.,
Chowienczyk P. J.,
Shaw K. M.,
Cummings M. H.
Publication year - 2000
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2000.00241.x
Subject(s) - medicine , forearm , plethysmograph , vasodilation , diabetes mellitus , endocrinology , surgery
Summary Aims To compare the vasodilatory responses to substance P in human forearm vessels in Type 1 normoalbuminuric diabetic and non‐diabetic subjects. Methods Forearm blood flow (FBF) was measured using a plethysmography technique in 12 normoalbuminuric Type 1 diabetic subjects (six males, six females) (HbA 1C 8.2 ± 0.3% (mean ± sem )) and 12 non‐diabetic healthy control subjects in response to the infusion of the vasodilators substance P (SP), acetylcholine (ACh) and nitroprusside. Results There was no significant difference in baseline FBF between the two groups (2.80 ± 0.29 ml/min per 100 ml forearm tissue (diabetic group) vs. 2.85 ± 0.37 ml/min per 100 ml (non‐diabetic group), P = 0.45). Infusion of SP was associated with an incremental increase in FBF in the diabetic (0.6, 2 and 6 ng/min – 6.08 ± 1.07, 7.82 ± 1.08 and 9.48 ± 1.14 ml/min per 100 ml, respectively) and the non‐diabetic group (0.6, 2 and 6 ng/min – 5.41 ± 0.80, 6.93 ± 0.96 and 9.25 ± 1.11 ml/min per 100 ml, respectively). Similarly, an incremental rise in FBF was observed during infusion of ACh (diabetic group: 7.5, 15 and 30 μg/min – 7.14 ± 1.22, 8.91 ± 1.40 and 11.67 ± 1.93 ml/min per 100 ml, respectively; non‐diabetic group: 7.5, 15 and 30 μg/min – 5.87 ± 0.81, 7.49 ± 0.96 and 10.74 ± 1.29 ml/min per 100 ml, respectively). When FBF was expressed as percentage change from baseline, there was no significant difference in vasodilatory responses between the two groups for SP (0.6 ng/min, P = 0.21; 2 ng/min, P = 0.19; 6 ng/min, P = 0.19) or ACh (7.5 μg/min, P = 0.20; 15 μg/min, P = 0.20; 30 μg/min, P = 0.35). Conclusions This study suggests that endothelium‐dependent vasodilatory responses to SP (and ACh) are not impaired in Type 1 diabetic subjects with normal urinary albumin excretion.