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The effect of long‐term glycaemic control on serum lipoprotein(a) levels in patients with Type 2 diabetes mellitus
Author(s) -
Song K. H.,
Ahn Y. B.,
Yoon K. H.,
Cha B. Y.,
Lee K. W.,
Son H. Y.,
Kang S. K.
Publication year - 1999
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.1999.00183.x
Subject(s) - medicine , lipoprotein(a) , diabetes mellitus , type 2 diabetes mellitus , type 2 diabetes , lipoprotein , endocrinology , gastroenterology , cholesterol
Summary Aims To examine whether long‐term glycaemic control affects lipoprotein(a) (Lp(a)) levels in patients with Type 2 diabetes mellitus. Methods Eighty‐nine Type 2 diabetic patients (38 men, 51 women) were recruited from the diabetes clinic. Based on HbA 1c concentrations at baseline, patients were divided into two groups: those with HbA 1c < 8.0% ( n = 45) and those with HbA 1c ≥ 8.0% ( n = 44). Comparisons of Lp(a) levels were made between both groups. The effect of long‐term glycaemic control on Lp(a) levels was investigated in a subgroup of 20 patients, selected from those with baseline HbA 1c ≥ 8%. All these patients were treated with a goal of HbA 1c < 7%. Results Lp(a) levels were not significantly different between those with HbA 1c < 8.0% and those with HbA 1c ≥ 8.0%. No correlation between Lp(a) and HbA 1c or fasting blood glucose levels was noted in diabetic patients as a whole. After 2 years of intensive glycaemic control, all patients exhibited remarkable improvement of therapy: their average HbA 1c levels were 6.5 ± 0.7%, being < 7% in 70% of patients. However, no change in Lp(a) levels were observed after 2 years (19.5 ± 14.8–21.4 ± 13.4 mg/dl, P = 0.390). Conclusion These results indicate that improvement of glycaemic control does not affect serum Lp(a) levels in patients with Type 2 diabetes mellitus.