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Type 1 diabetes mellitus, coeliac disease, and lymphoma: a report of four cases
Author(s) -
O’connor T. M.,
Cronin C. C.,
Loane J. F.,
O’meara N. M.,
Firth R. G.,
Shanahan F.,
O’halloran D. J.
Publication year - 1999
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.1999.00123.x
Subject(s) - medicine , coeliac disease , lymphoma , gastroenterology , diabetes mellitus , disease , malignancy , gluten free , type 2 diabetes mellitus , endocrinology
Summary Introduction Patients with Type 1 diabetes mellitus have a high prevalence of coeliac disease, symptoms of which are often mild, atypical, or absent. Untreated coeliac disease is associated with an increased risk of malignancy, particularly of lymphoma. We describe four patients with Type 1 diabetes mellitus and coeliac disease who developed lymphoma. Case reports Two patients were male and two female. In three patients, coeliac disease and lymphoma were diagnosed simultaneously. Enteropathy‐associated T cell lymphoma occurred in two patients, Hodgkin’s disease in one, and B cell lymphoma in one. Response to treatment was in general poor, and three patients died soon after the diagnosis of lymphoma was made. Conclusion As the relative risk of lymphoma is reduced by a gluten‐free diet, a high index of suspicion for coeliac disease should exist in all Type 1 diabetic patients with unexplained constitutional or gastro‐ intestinal symptoms. Keywords coeliac disease, lymphoma, Type 1 diabetes mellitus