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Long‐term efficacy of Humalogã in subjects with Type 1 diabetes mellitus
Author(s) -
Garg S. K.,
Anderson J. H.,
Perry S. V.,
Mackenzie T.,
Keith P.,
Jennings M. K.,
Hansen M. M.,
Chase H. P.
Publication year - 1999
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.1999.00066.x
Subject(s) - medicine , postprandial , insulin lispro , meal , insulin , human insulin , diabetes mellitus , endocrinology
Summary Aims To evaluate the long‐term effectiveness of Humalog® insulin in lowering post meal glucose excursions. Methods Twenty young subjects with Type 1 diabetes mellitus (DM) who had received insulin‐lispro (Humalog®) for a least 1 year (mean ± SD 1.8 ± 1.6 years) were studied on two occasions, 3–14 days apart. They consumed a similar breakfast consisting of 450–600 kCal having fasted overnight. The same amount of human soluble Humulin® Regular or Humalog® insulin was given 10 min before the meal in a randomized, double‐blind fashion. Results Postprandial glucose excursions at 30, 60, and 120 min were significantly lower ( P < 0.001, ancova ) when subjects received Humalog® as compared to human soluble insulin. Serum‐free insulin levels were significantly higher ( P < 0.001, anova ) at 30 and 60 min when subjects received Humalog® as compared with human soluble insulin. Humalog® antibody levels after up to 5.4 years of receiving Humalog® insulin were not elevated beyond the values at 1 year. Conclusions We conclude that Humalog® insulin is effective in lowering postprandial glucose excursions even after up to 5.4 years of treatment.