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Autonomic neuropathy in Type 2 diabetic patients is associated with hyperinsulinaemia and hypertriglyceridaemia
Author(s) -
Gottsäter A.,
Ahmed M.,
Fernlund P.,
Sundkvist G.
Publication year - 1999
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.1999.00001.x
Subject(s) - medicine , endocrinology , type 2 diabetes , body mass index , insulin resistance , renal function , diabetes mellitus , diabetic neuropathy , triglyceride , gastroenterology , cholesterol
Aims To clarify whether parasympathetic neuropathy in Type 2 diabetic patients is associated with features of the insulin resistance syndrome. Methods Blood pressures, glycaemic control (HbA 1c ), plasma lipids, residual β‐cell function (fasting plasma C‐peptide), autonomic nerve function, urinary albumin excretion and glomerular filtration rate (Cr‐EDTA clearance) were evaluated in 82 Type 2 diabetic patients (age 61 ± 1 years) 5 years after diagnosis of diabetes. Results Parasympathetic neuropathy (an abnormal age corrected E/I ratio) was found in 24/82 (29%) patients. After adjustment for body mass index (BMI), patients with parasympathetic neuropathy had elevated fasting plasma C‐peptide ( P < 0.001) and triglyceride (Tg) ( P < 0.05) levels compared with patients without parasympathetic neuropathy. In addition, the age corrected E/I ratio correlated inversely with Tg ( r = –0.31; P < 0.01) and fasting plasma C‐peptide ( r = – 0.32; P < 0.01) in the Type 2 diabetic patients. Conclusion Autonomic neuropathy 5 years after diagnosis of Type 2 diabetes is associated with an unfavourable metabolic risk profile. Diabet. Med. 16, 49–54 (1999)