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99m Technetium‐C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer
Author(s) -
Simms M.S.,
Perkins A.C.,
Price M.R.,
Scholfield D.P.,
Bishop M.C.
Publication year - 2001
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1046/j.1464-410x.2001.02348.x
Subject(s) - immunoscintigraphy , medicine , transitional cell carcinoma , technetium , cystectomy , bladder cancer , radiology , technetium 99m , nuclear medicine , urinary bladder , single photon emission computed tomography , cancer , scintigraphy , radioimmunotherapy , monoclonal antibody , urology , antibody , immunology
Objectives To assess whether immunoscintigraphy using a conjugate of the anti–MUC1 monoclonal antibody C595 and 99m Tc could be used to target transitional cell bladder cancer after intravenous administration to patients. Patients and methods Twenty‐one patients with invasive or metastatic transitional cell carcinoma were recruited. Patients received 1 mg of C595 labelled with 800 MBq 99m Tc followed by imaging at 0.5, 6 and 24 h using a combination of planar and single‐photon emission computed tomography. Of these patients, 14 subsequently underwent cystectomy, four underwent radiotherapy and the remaining three had histologically confirmed metastatic disease. The results of immunoscintigraphy were compared with surgical findings and conventional radiology. Results There were no adverse reactions in any patient. Of the 20 patients who were found to have tumour at the time of the study, positive localization of antibody in tumour was apparent in 16. Of the remaining four patients, false‐positive localization of antibody in presumed nodal tissue was detected in two. The remaining scan results were equivocal. In three patients, histologically confirmed pelvic nodal metastases that had not been detected on preoperative computed tomography were identified. Conclusion These early results show the potential of 99m Tc‐C595 immunoscintigraphy for staging bladder cancer. A larger study is needed to fully evaluate the technique.