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Urinary levels of substance P and its metabolites are not increased in interstitial cystitis
Author(s) -
Campbell D.J.,
Tenis N.,
Rosamilia A.,
Clements J.A.,
Dwyer P.L.
Publication year - 2001
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1046/j.1464-410x.2001.00990.x
Subject(s) - interstitial cystitis , urine , excretion , diuresis , substance p , urology , medicine , urinary system , endocrinology , urinary bladder , indwelling catheter , chemistry , renal function , catheter , surgery , neuropeptide , receptor
Objectives To determine whether interstitial cystitis is associated with the increased release of substance P from the bladder wall into urine, by measuring urinary excretion rates of substance P and its metabolites in women with interstitial cystitis and in a control group of women with stress incontinence and normal bladder function. Patients and methods Catheter urine was collected from 13 patients and 10 controls during a water diuresis (≈ 10 mL/min) before and after instilling the bladder with 100 mL of water. The contribution of the bladder wall to urinary substance P peptides was assessed by measuring the change in substance P peptide levels after 2 min of bladder stasis before and after instillation. Results Absolute substance P excretion rates were similar in patients with interstitial cystitis and controls; 2 min of bladder stasis reduced the substance P excretion rate ( P = 0.03) and increased the excretion rate of substance P metabolites ( P = 0.01). Conclusions The release of substance P from the bladder wall was not increased in patients with interstitial cystitis.