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Low frequency of microsatellite instability in hereditary prostate cancer
Author(s) -
Åhman A.K.,
Jonsson B.A.,
Damber J.E.,
Bergh A.,
Grönberg H.
Publication year - 2001
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1046/j.1464-410x.2001.00104.x
Subject(s) - microsatellite instability , prostate cancer , microsatellite , cancer , dna mismatch repair , prostate , biology , genetics , colorectal cancer , oncology , medicine , cancer research , gene , allele
Objective To investigate whether there is widespread microsatellite instability (MSI) in families with hereditary prostate cancer (HPC). Patients and methods Eighty‐four prostate tumours from 80 Swedish men in 35 families with HPC were screened for genetic instability at microsatellite marker loci BAT‐25, BAT‐26, BAT‐34C4, D2S123 and D17S250. Results MSI was detected in only five individuals from different families. Three tumours (4%) were unstable at more than two MSI loci and hence classified as high‐frequency MSI (MSI‐H) according to a previous definition. Interestingly, two of the MSI‐H tumours were from patients in families with both HPC and familial colon cancer. Conclusions Widespread MSI is a rare event in hereditary prostate cancer, indicating that defective DNA mismatch repair is not an important element in the genesis of HPC.