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Adjuvant mitozantrone chemotherapy in advanced prostate cancer
Author(s) -
Wang J.,
Halford S.,
Rigg A.,
Roylance R.,
Lynch M.,
Waxman J.
Publication year - 2000
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1046/j.1464-410x.2000.00894.x
Subject(s) - medicine , flutamide , prostate cancer , adjuvant , hormonal therapy , oncology , chemotherapy , cancer , prostate , urology , androgen receptor
Objective To assess the role of mitozantrone, active in relapsed prostate cancer, as an adjuvant to hormonal treatment in patients with advanced prostate cancer. Patients and methods Between October 1990 and May 1995, 96 patients were entered into a stratified, randomized, single‐institution study of hormonal therapy with a luteinizing hormone‐releasing hormone agonist and flutamide, with or without four cycles of adjuvant mitozantrone. Of these, 93 patients were evaluable and the results were analysed in June 1999. Results Patients with localized prostate cancer receiving adjuvant chemotherapy had a higher initial objective response rate (95% vs 53%, P = 0.008) and median survival (80 vs 36 months, P = 0.04) than patients who were treated with hormonal therapy alone. There was no advantage to adjuvant chemotherapy in patients with metastatic prostate cancer. There were insignificant advantages to chemotherapy in overall response rates (55% vs 39%, P = 0.3) and PSA responses (82% vs 64%, P = 0.11). There was no difference between the patient groups in time to treatment failure. Conclusion There was a survival advantage in using adjuvant mitozantrone in patients with locally advanced prostate cancer. Although the study comprised relative few patients, the follow‐up period was long and the advantage significant. We recommend that the study be extended to include more patients.