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Contemporary results of radical radiotherapy for bladder transitional cell carcinoma in a district general hospital with cancer‐centre status
Author(s) -
; Bell,
Lydon,
Kernick,
Hong Li,
Pocock,
Stott
Publication year - 1999
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1046/j.1464-410x.1999.00009.x
Subject(s) - medicine , radiation therapy , transitional cell carcinoma , cancer , oncology , bladder cancer , general surgery
Objective To assess the current efficacy and safety of definitive external beam radiotherapy (EBRT) in the treatment of invasive bladder transitional cell carcinoma (TCC) in a district general hospital with cancer‐centre status. Patients and Methods The case notes of all patients with bladder TCC undergoing EBRT with curative intent over an 8‐year period (1988–95) were reviewed. Additional missing outcome data were collected. Results In all, 120 patients (109 men; median age 70 years, range 34–90) underwent radical EBRT (40–65 Gy; fraction median=20) over the 8‐year period. Staging, as assessed by examination under anaesthesia and computed tomography, was T1 in 16%, T2 in 43%, T3 in 38% and T4 in 3%. In 96 patients (80%) the tumour was poorly differentiated (G3). The overall morbidity at 12 months was 12%; proctitis occurred in nine patients (8%) and cystitis in five (4%). Sixty‐seven patients (59%) developed a local recurrence and in 36 (30%) this was invasive. The overall median survival was 60 months. Thirty‐three patients underwent salvage cystectomy with a subsequent median survival of 12.5 months. Conclusion Modern radical multifraction EBRT in invasive bladder TCC has a low morbidity, with an overall median survival of 5 years.