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The long‐term effects of prostatic infarction in the rat
Author(s) -
M. S. Park,
Andrew K. Lee,
S. E. Lee
Publication year - 1998
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1046/j.1464-410x.1998.00798.x
Subject(s) - prostate , atrophy , hyperplasia , medicine , infarction , urology , pathology , endocrinology , myocardial infarction , cancer
Objective To evaluate the long‐term effects of infarction, which usually induces organ atrophy, on the prostate by examining the changes occurring in rat ventral prostate after infarction. Materials and methods The unilateral arteriolar branches to the ventral prostate were electrocauterized under an operative microscope in 10 adult rats. The gross and histological changes of the treated lobes of the ventral prostate were compared with those of untreated control lobes in the same rats 12 weeks later. Results The size and mean (sd) weight of the treated lobes decreased markedly, to 148 (34) mg, compared with those of the controls, at 698 (62) mg ( P <0.01). The treated lobes were composed of both normal and atrophic glandular tissue. Conclusion Prostatic atrophy can be induced by infarction in the rat; prostatic infarction might have potential as a new therapeutic strategy in the treatment of benign prostatic hyperplasia.