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The source of urinary nitrosamines in patients with enterocystoplasties
Author(s) -
Creagh T.A.,
Picramenos D.,
Smalley E.T.,
Walters C.L.,
Mundy A.R.
Publication year - 1997
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1046/j.1464-410x.1997.02686.x
Subject(s) - nitrosamine , bacteriuria , urinary system , urine , urology , urinary bladder , medicine , gastroenterology , chemistry , carcinogen , organic chemistry
Objective To assess the factors influencing urinary nitrosamine production in patients with enterocystoplasties. Patients, subjects and methods The study comprised 100 patients with an enterocystoplasty, 20 patients with interstitial cystitis, 30 with infective cystitis and 120 control subjects drawn from hospital staff and out‐patients. Urinary nitrosamine levels were measured and the urine samples cultured for micro‐organisms. Results Nitrosamine levels were significantly higher only in patients with enterocystoplasties who also had higher urinary white cell counts or significant bacteriuria. Conclusion Patients with an enterocystoplasty and significant bacteriuria are most at risk from potential nitrosamine‐induced epithelial injury.