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Effect of oral administration of prostaglandin E1
Author(s) -
SATO Y.,
HORITA H.,
ADACHI H.,
SUZUKI N.,
TANDA H.,
KUMAMOTO Y.,
TSUKAMOTO T.
Publication year - 1997
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1046/j.1464-410x.1997.00466.x
Subject(s) - prostaglandin e1 , nocturnal penile tumescence , medicine , erectile dysfunction , erectile function , tumescence , urology , anesthesia , surgery
Objectives To investigate the effect of limaprost, an oral prostaglandin E1 (PGE1) derivative, on erectile dysfunction and to compare the effects of limaprost with a Chinese herbal drug, gosyajinki‐gan. Patients and methods The study comprised 50 consecutive patients with mild erectile dysfunction who showed a good erectile response to intracavernosal injection with 20 &mgr;g of PGE1. Limaprost was administered to the first 25 patients (30 &mgr;g three times daily) and gosyajinki‐gan (7.5 g three times daily) to the next 25 patients, for 8 consecutive weeks. Patients were evaluated by their ability to achieve vaginal penetration and by a subjective assessment of erectile function (penile rigidity and maintenance of erection) before and after the treatment, using a self‐administered questionnaire. Objective measurements (nocturnal penile tumescence, NPT, values) were also evaluated. Results Eleven of the 24 patients who received limaprost without interruption and four of the 24 taking gosyajinki‐gan succeeded in vaginal penetration; the difference in the positive response rate was significant. The mean increment of NPT was significantly higher with limaprost treatment. However, all positive responders in both groups did not experience a full erection. There were no side‐effects in any patient except one in the limaprost group who developed a facial flush. Thus the treatment was mild enough to be tolerated. Conclusion Limaprost was more effective for mild erectile dysfunction than was gosyajinki‐gan.