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Neuroendocrine differentiation and prognosis in prostatic adenocarcinoma
Author(s) -
McWILLIAM L.J.,
MANSON C.,
GEORGE N.J.R.
Publication year - 1997
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1046/j.1464-410x.1997.00300.x
Subject(s) - chromogranin a , neuroendocrine differentiation , enolase , prostatic adenocarcinoma , immunohistochemistry , adenocarcinoma , medicine , synaptophysin , pathology , oncology , cancer , prostate cancer
Objectives To assess the prognostic importance of neuroendocrine differentiation in conventional (non‐small cell) prostatic adenocarcinoma. Materials and methods Ninety‐two samples from patients with prostatic adenocarcinoma were studied retrospectively. The immunohistochemical analysis of chromogranin A and neuron‐specific enolase in formalin‐fixed, paraffin wax embedded prostatic tissue chips was related to other prognostic variables and patient survival. Results Neuroendocrine differentiation was detected in 48 cases; there was a significant correlation with worsening tumour differentiation, the presence of bone metastases and with worsening survival, but no independent effect of neuroendocrine differentiation on survival. Conclusion The detection of neuroendocrine differentiation in conventional prostatic adenocarcinoma is not an independent indicator of prognosis.