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A feasibility study for the non‐invasive treatment of superficial bladder tumours with focused ultrasound
Author(s) -
Watkin N.A.,
Morris S.B.,
Rivens I.H.,
Woodhouse C.R.J.
Publication year - 1996
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1046/j.1464-410x.1996.02189.x
Subject(s) - urothelium , ultrasound , medicine , extracorporeal , urinary bladder , urology , animal model , focused ultrasound , pathology , surgery , radiology
Objective To determine whether high‐intensity focused ultrasound can be used to ablate bladder wall tissue using a transabdominal approach in a large animal model, and whether it can be developed as a non‐invasive treatment for superficial bladder tumours. Materials and methods The bladder wall of 25 large white pigs was treated with a 1.7 MHz extracorporeal focused‐bowl ultrasonic transducer. Animals were killed either 2 h, 3 days or 4 weeks after treatment and the bladder wall examined macroscopically and histologically. Results Acute bladder wall damage was detected in 15 of 16 animals at 2 h and in all six animals examined after 3 days. Areas of healing were seen in 10 of 12 animals at 4 weeks. Histological analysis of the treated areas revealed that the urothelium was denuded within 2 h and was associated with an acute inflammatory response in the bladder wall. At 4 weeks, the urothelium had regenerated over a maturing scar. Conclusions Focused ultrasound can be used successfully to destroy regions of the bladder wall in a large animal model in vivo .