Premium
The role of volume‐weighted mean nuclear volume in predicting tumour biology and clinical behaviour in patients with prostate cancer undergoing watchful waiting
Author(s) -
Arai Y.,
Egawa S.,
Kuwao S.,
Ogura K.,
Baba S.
Publication year - 2001
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1046/j.1464-4096.2001.01558.x
Subject(s) - watchful waiting , prostate cancer , medicine , proportional hazards model , prostate , urology , prostate specific antigen , cancer , doubling time , population , biopsy , multivariate analysis , oncology , biology , cell , genetics , environmental health
Objective To investigate whether the volume‐weighted mean nuclear volume (MNV, the only means by which unbiased estimates of three‐dimensional variables can be obtained from a two‐dimensional section by stereological methods) at diagnosis correlates with tumour biology and clinical behaviour in patients with prostate cancer treated by watchful waiting. Patients and methods In a prognostic study, 64 patients with clinically localized prostate cancer were followed prospectively with initial expectant management. The median (mean, range) follow‐up was 22 (27, 6.0–68) months. The prostate specific antigen (PSA) doubling time (PSADT) was calculated by linear regression. The MNV was estimated using biopsy specimens, based on a stereological method, and compared with PSADT and traditional clinicopathological variables. Results PSADT was significantly associated with MNV, but not with other clinicopathological variables. The PSA ‘rapid‐riser’ subset (PSADT