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Effects of twice daily application of 2% dorzolamide on intraocular pressure in normal cats
Author(s) -
Rainbow Marc E.,
Dziezyc Joan
Publication year - 2003
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1046/j.1463-5224.2003.00282.x
Subject(s) - dorzolamide , intraocular pressure , cats , medicine , glaucoma , ophthalmology , carbonic anhydrase inhibitor , anesthesia , carbonic anhydrase , chemistry , timolol , enzyme , biochemistry
The effect of the topical carbonic anhydrase inhibitor, dorzolamide, on intraocular pressure in cats was studied. The intraocular pressure of both eyes of eight healthy cats was measured using applanation tonometery (Tono‐Pen) during two phases: control and treatment. Both eyes were treated with 2% dorzolamide twice a day during the treatment phase. Application of dorzolamide resulted in a significant decrease of intraocular pressure over the treatment phase. By the fourth and fifth day of treatment, the mean intraocular pressure (± standard deviation) was 9.7 (± 1.5) mmHg, whereas the mean (± standard deviation) for the last 2 days of the control period was 12.2 (± 2.0) mmHg. Based on this study, dorzolamide is a potentially effective treatment for glaucoma in cats, significantly lowering intraocular pressure.