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Neuroepithelial tumor of the retina in a dog
Author(s) -
Jensen Ove A.,
Kaarsholm Susanne,
Prause Jan U.,
Heegaard Steffen
Publication year - 2003
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1046/j.1463-5224.2003.00268.x
Subject(s) - neuroepithelial cell , retina , retinoblastoma , pathology , clone (java method) , biology , immunohistochemistry , anatomy , retinal , malignant transformation , stem cell , medicine , microbiology and biotechnology , neural stem cell , neuroscience , biochemistry , genetics , gene , dna
Animal studied At routine vaccination a tumor in the right eye of a Golden Retriever was diagnosed. Procedure The eye was enucleated, fixed in formalin and processed according to routine paraffin technique. Standard histologic, histochemical and immunohistochemical stainings were applied. Formalin‐fixed tissue was used for electron microscopic examination. Results The tumor originated from the retina and was composed of two different morphologic parts, a retinoblastoma‐like part of small neuroepithelial cells and a medulloepithelioma‐like part of columnar cells arranged in cords. Discussion and conclusion It is discussed whether the tumor had its origin in different clones or in one clone, and it is suggested that the double differentiation might be the result of a transformation of retinal cells, demasking stem cell‐like potentials.