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Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration
Author(s) -
Bromberg Nancy M.
Publication year - 2002
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1046/j.1463-5224.2002.00216.x
Subject(s) - cyanoacrylate , medicine , refractory (planetary science) , debridement (dental) , corneal ulceration , surgery , cornea , corneal neovascularization , corneal ulcer , sedation , adhesive , neovascularization , ophthalmology , chemistry , physics , organic chemistry , layer (electronics) , astrobiology , angiogenesis
Isobutyl cyanoacrylate tissue adhesive (BCTA) was used in the treatment of refractory superficial corneal ulcers in 17 dogs, one cat, and one rabbit, present 2 weeks to 7 months (mean 6.8 weeks ± 6.1) prior to referral. Little to no sedation was required in the majority of cases, with only topical anesthetic applied prior to debridement and BCTA application. The presence of the tissue adhesive caused mild discomfort for several days after application, as reported by the owners. The ulcers healed, and the tissue adhesive sloughed in approximately 3 weeks (± 1 week). Mild neovascularization of the cornea resolved with topical corticosteroids. The use of BCTA offers a simple, safe and noninvasive treatment for refractory corneal ulcers.