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Effect of topical 1% atropine sulfate on intraocular pressure in normal horses
Author(s) -
Herring Ian P.,
Pickett J. Phillip,
Champagne Erin S.,
Troy Gregory C.,
Marini Michele
Publication year - 2000
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1046/j.1463-5224.2000.3230139.x
Subject(s) - atropine , atropine sulfate , medicine , horse , intraocular pressure , ophthalmology , anesthesia , biology , paleontology
Objective To determine the effect of topical 1% ophthalmic atropine sulfate on intraocular pressure (IOP) in ocular normotensive horses. Animals Studied Eleven clinically healthy horses. Procedures IOP was measured bilaterally twice daily, at 8 am and 4 pm , for 5 days. No medication was applied for the first 2 days of the study. Thereafter, one eye of each horse was treated with 0.1 mL of topical 1% atropine sulfate ointment twice daily (7 am and 7 pm ) for 3 days. The contralateral eye served as a control. In eight of the horses, an additional IOP reading was taken 3 days following cessation of the atropine treatment. Results There was no significant difference in the IOP of control vs. treatment eyes in the pretreatment period, days 1 and 2 ( P = 0.97 and 0.55, respectively). During the treatment period, treated eyes of 10 of the horses had significantly lower IOP than control eyes ( P = 0.03). The mean IOP reduction in treated eyes, relative to untreated eyes, was 11.2%. One horse had a significant rise in IOP in the treated eye compared to the remaining study animals. The IOP of control eyes did not vary significantly over the observation period ( P = 0.27). There was no significant variation in IOP between the 8 am and 4 pm measurement ( P = 0.9). Conclusions Topical 1% atropine sulfate causes a small, but significant decline in IOP in most ocular normotensive horses. Because topical atropine may elevate IOP in some horses, it should be used with caution in the treatment of glaucoma in this species.