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p53 protein expression in conjunctival squamous cell carcinomas of domestic animals
Author(s) -
Sironi Giuseppe,
Riccaboni Pietro,
Mertel Luca,
Cammarata Giorgio,
Brooks Dennis E.
Publication year - 1999
Publication title -
veterinary ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.594
H-Index - 50
eISSN - 1463-5224
pISSN - 1463-5216
DOI - 10.1046/j.1463-5224.1999.00086.x
Subject(s) - immunostaining , immunohistochemistry , p53 protein , monoclonal antibody , pathology , biology , basal cell , cell , antibody , cancer research , microbiology and biotechnology , medicine , immunology , genetics
The expression of p53 protein was investigated in eight formalin‐fixed, paraffin‐embedded conjunctival squamous cell carcinomas of five horses and one cow, dog and cat each by an immunohistochemical procedure in order to evaluate protein overexpression. Anti‐human p53 protein mouse monoclonal antibodies known to be cross‐reactive with p53 protein of the animal species examined were used. Positive p53 nuclear immunostaining was detected in five equine, one bovine and one feline cases. Conversely, no p53 immunostaining was found in the only canine case examined. These results demonstrate a frequent p53 overexpression in conjunctival squamous cell carcinoma that could be related to UV‐induced mutations of the p53 tumor suppressor gene.