Premium
Comparison of thrice daily ‘high’ vs. ‘medium’ premixed insulin aspart with respect to evening and overnight glycaemic control in patients with type 2 diabetes
Author(s) -
Ejskjaer N.,
Rasmussen M.,
Kamp N.,
Lindholm A.,
Christiansen J. S.
Publication year - 2003
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1046/j.1463-1326.2003.00299.x
Subject(s) - postprandial , medicine , insulin aspart , morning , evening , endocrinology , type 2 diabetes , insulin , crossover study , diabetes mellitus , placebo , physics , alternative medicine , pathology , astronomy
Background: The glycaemic control of thrice daily treatment with premixed biphasic insulin aspart (BIAsp) without other antidiabetic therapy was tested in type 2 diabetic patients, in order to compare the glucose control of a ‘high’ mixture (BIAsp 70) or a ‘medium’ mixture (BIAsp 50) (70 or 50% soluble IAsp and 30 or 50% protamine‐crystallized IAsp, respectively) administered just before dinner. Aim: To compare these regimens to conventional 30 : 70 premixture on a twice a day basis. Methods: This randomized, double‐blind, two‐period crossover study included 16 patients with type 2 diabetes. Twenty four‐hour serum glucose and insulin profiles were obtained thrice: (1) after a one‐week run‐in period with biphasic human insulin (BHI) 30/70 twice daily (run‐in), (2) after 4 weeks of treatment with thrice daily BIAsp 70 before breakfast, lunch and dinner (Dinner70 regimen) and (3) after 4 weeks of BIAsp 70 before breakfast and lunch and BIAsp 50 before dinner (Dinner50). Results: Daytime average serum glucose was lower with Dinner70 compared to run‐in (9.6 ± 0.39 mmol/l vs. 11.2 ± 0.61 mmol/l, p < 0.05). Postprandial glucose excursions after breakfast and lunch were lower, but fasting morning glucose was higher during the treatment periods than in the run‐in period. Twenty four‐hour C‐peptide AUC was considerably lower during both treatment periods than in the run‐in period (run‐in/Dinner50 ratio 1.29 [1.08; 1.54] p < 0.01; run‐in/Dinner70 ratio 1.31 [1.08;1.58], p < 0.01). Conclusions: Switching the dinner dose to BIAsp 50 did not alter overall glucose control significantly from that provided with BIAsp 70. Exploratory analyses between the two active treatment regimens and run‐in/BHI indicate that thrice daily BIAsp 70 administration: (1) for optimization of the night‐time control, the dinner dose needs adjustment or replacement by a premixed insulin with a larger proportion of basal insulin than BIAsp 50 and (2) none of the premixtures adequately provide for both the evening meal and overnight requirements.