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TRP64ARG polymorphism of the β3‐adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle
Author(s) -
Marti A.,
Corbalán M. S.,
MartínezGonzalez M. A.,
Martinez J. A.
Publication year - 2002
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1046/j.1463-1326.2002.00227.x
Subject(s) - obesity , medicine , body mass index , confounding , beta 3 adrenergic receptor , logistic regression , polymorphism (computer science) , endocrinology , sedentary lifestyle , genotype , adrenergic receptor , receptor , gene , biology , genetics
Aim: We performed a case–control study to assess the association between obesity risk and the Trp64Arg polymorphism of the β 3 ‐adrenergic receptor gene. Methods: Obese subjects [n = 159; body mass index (BMI) > 30 kg/m 2 ] and controls (n = 154; BMI < 25 kg/m 2 ) were compared using multivariable logistic regression to control for potential confounders. Results: A higher obesity risk (adjusted OR: 2.98; 95% CI: 1.00–8.56; p = 0.05) was associated with the Trp64Arg polymorphism among sedentary, but not among more active people. Conclusions: Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle.