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Effects of arachidonic acid plus zinc on glucose disposal in genetically diabetic ( ob/ob ) mice
Author(s) -
Hwang I. K.,
Go V. L. W.,
Harris D. M.,
Yip I.,
Song M. K.
Publication year - 2002
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1046/j.1463-1326.2002.00195.x
Subject(s) - postprandial , medicine , endocrinology , zinc , insulin , diabetes mellitus , arachidonic acid , chemistry , biochemistry , organic chemistry , enzyme
Aim: The present study is designed to determine whether arachidonic acid (AA) plus zinc improves clinical signs of diabetes in genetically diabetic ob/ob mice. Methods: In the first study, effects of acute administration of AA plus zinc on glucose disposal were determined in ob/ob and lean mice (n = 6 each). In the second study, ob/ob and lean mice were treated with increasing doses of AA plus zinc for 2 weeks (n = 5 each). Postprandial and fasting blood glucose concentrations, three‐hour‐area‐average above fasting glucose concentration (TAFGC), water and food intake, body weight and plasma insulin concentrations were measured. Results: Acute administration of AA plus zinc significantly increased glucose disposal in ob/ob mice. In the second study, postprandial and fasting blood glucose concentrations, TAFGC, and water and food intake in ob/ob mice treated with AA plus zinc for 2 weeks were significantly decreased compared with those in mice given no AA. Plasma insulin concentrations in both lean and ob/ob mice were not changed by AA treatment in drinking water. Conclusions: AA plus zinc in drinking water is effective in decreasing blood glucose levels in obese mice. These results indicate that use of these compounds should be considered as a dietary supplement to control hyperglycaemia in patients with type II diabetes.