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Effects of the Magenstrasse and Mill operation for obesity on plasma leptin and insulin resistance
Author(s) -
Carmichael A. R.,
Johnston D.,
King R. F. G. J.,
SueLing H. M.
Publication year - 2001
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1046/j.1463-1326.2001.00129.x
Subject(s) - insulin resistance , medicine , leptin , endocrinology , insulin , obesity , body mass index , homeostasis , morbidly obese , weight loss , chemistry
Summary Background We evaluated the effect of the Magenstrasse and Mill (M & M) operation–a new form of non‐banded vertical gastroplasty–on weight loss, plasma leptin levels and insulin resistance. Methods Fasting plasma glucose, leptin and insulin levels were measured in 12 normal controls, 39 morbidly obese patients and 39 patients a median 3 years after the M & M procedure. Insulin resistance was calculated by the homeostasis model insulin resistance index. Results Body mass index mean (s.d.) decreased significantly (p < 0.0001), from 48(7) to 33(5) kg/m 2 , after the M & M procedure. Fasting plasma leptin concentration in the morbidly obese group was 37.9(15.4) ng/ml, significantly (p < 0.0001) higher than the control group (12.2(8.4)) and the M & M group (19.1(12.7)) ng/ml. Fasting plasma insulin concentrations were also significantly (p < 0.0001) higher in the morbidly obese group compared with than in the M & M group or in the control group: 35.5(22.3) mU/l, 15.5(7.1) mU/l and 13.6(3.4) mU/l, respectively. Insulin resistance was 9.6(7.2) in the morbidly obese group and 3.5(1.9) in the M & M group (p < 0.0001). Conclusion This is one of the first studies to show that the decrease in insulin resistance after weight loss achieved by anti‐obesity surgery is associated with significantly lower levels of plasma leptin.