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Insulin resistance: the fundamental trigger of type 2 diabetes
Author(s) -
Groop L. C.
Publication year - 1999
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1046/j.1463-1326.1999.0010s1001.x
Subject(s) - insulin resistance , type 2 diabetes , endocrinology , medicine , diabetes mellitus , insulin , obesity , abdominal obesity , biology , impaired glucose tolerance , metabolic syndrome
Summary Summary. Type 2 diabetes is a heterogeneous condition that is not attributable to a single pathophysiological mechanism. In general, both insulin resistance and impaired insulin secretion are required for the disease to become manifest. Thus, as long as the pancreatic β cells can compensate for the degree of insulin resistance, glucose tolerance remains normal. Clustering of type 2 diabetes in certain families and ethnic populations points to a strong genetic background for the disease. However, environmental factors such as obesity and a sedentary lifestyle are usually required to unmask the genes.