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Lowering of circulating insulin and leptin is closely associated following weight reduction after vertical banded gastroplasty in obese women
Author(s) -
Guldstrand M.,
Backman L.,
Adamson U.,
Lins P. E.,
Ahrén B.
Publication year - 1999
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1046/j.1463-1326.1999.00005.x
Subject(s) - leptin , medicine , insulin , endocrinology , obesity , weight loss , reduction (mathematics) , geometry , mathematics
Summary Aim : To explore whether the lowering of insulin relates to changes in leptin following weight reduction after vertical banded gastroplasty (VBG) in seven grossly obese women (BMI 45.9 ± 1.5 kg/m 2 ). Results : At 6–24 months after VBG, BMI was reduced to 31.3 ± 0.9 kg/m 2 (p < 0.018), leptin from 43 ± 9 to 12 ± 2 ng/ml (p < 0.018) and insulin from 172 ± 19 to 71 ± 2 pmol/l (p=0.018). The reduction in leptin correlated to the reduction in insulin ( r = 0.94, p = 0.002) but not to that of BMI ( r = 0.05, NS). Conclusion : Reduction in insulin seems more important for reduction in leptin than lowering of BMI, suggesting a close association between leptin and insulin in obese subjects.