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Moricizine Induced Increase in Pacing Threshold
Author(s) -
GIROD JOHN P.,
MARROUCHE NASSIR,
CHEN MICHAEL S.,
NATALE ANDREA
Publication year - 2003
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1046/j.1460-9592.2003.00160.x
Subject(s) - medicine , amiodarone , cardiology , myocardial infarction , ventricular tachycardia , anesthesia , cardiac pacing , tachycardia , heart block , implantable cardioverter defibrillator , ventricular pacing , electrocardiography , heart failure , atrial fibrillation
GIROD, J.P., et al. : Moricizine Induced Increase in Pacing Threshold.A 72‐year‐old woman who was experiencing incessant ventricular tachycardia and recurrent automatic implantable cardioverter defibrillator (AICD) firing despite amiodarone therapy was referred to the Cleveland Clinic Foundation. Myocardial ischemia and infarction were ruled out by standard means. Several antiarrhythmic medications were tried previously without success. Moricizine, 200 mg three times daily, was initiated and controlled the ventricular tachycardia. However, after the dose of moricizine was titrated upward, the patient became symptomatically bradycardic and the ECG exhibited 2:1 block of her paced rhythm and an increased ventricular pacing threshold. (PACE 2003; 26[Pt. I]:110–111)