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Angiotensin‐Converting Enzyme and Endothelial Nitric Oxide Synthase Polymorphisms in Patients with Atrial Fibrillation
Author(s) -
GENSINI FRANCESCA,
PADELETTI LUIGI,
FATINI CINZIA,
STICCHI ELENA,
FRANCO GENSINI GIAN,
MICHELUCCI ANTONIO
Publication year - 2003
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1046/j.1460-9592.2003.00036.x
Subject(s) - enos , medicine , genotype , angiotensin converting enzyme , atrial fibrillation , nitric oxide synthase , allele , endocrinology , endothelial dysfunction , nitric oxide , pathophysiology , endothelial nos , cardiology , genetics , blood pressure , biology , gene
GENSINI, F., et al. ; Angiotensin‐Converting Enzyme and Endothelial Nitric Oxide Synthase Polymorphisms in Patients with Atrial Fibrillation.Experimental studies have shown a significant increase in angiotensin‐converting enzyme (ACE) expression in atrial tissue of AF patients. ACE regulates the synthesis of endothelial nitric oxide (NO), which modulates autonomic nervous activity involved in the development of AF. The aim of the study was to evaluate the prevalence of ACE insertion/deletion and endothelial NO synthase (eNOS) T‐786C, G894T, and 4a/4b polymorphisms in 148 patients with persistent AF, compared with 210 control subjects. ACE insertion/deletion polymorphism genotype distribution and allele frequency were significantly different between patients and controls (P < 0.0001andP < 0.0001, respectively). ACE DD genotype was significantly associated with the risk of AF(OR DD/ID + II = 3.24, P < 0.0001). Analysis of eNOS polymorphisms showed no significant difference in genotype distribution and allele frequency between patients and controls. The results suggest a possible role of ACE DD genotype as a predisposing factor to AF and a pathophysiological mechanism of ACE inhibition in reducing the incidence of AF in patients with left ventricular dysfunction. (PACE 2003; 26[Pt. II]:295–298)