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Unconscious sedation in children: a prospective multi‐arm clinical trial
Author(s) -
Bauman Loren A.,
Can Michael L.,
McCloskey John,
Allen Sharon,
James Robert L.,
Tobin Joseph R.,
Politis George D.
Publication year - 2002
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.2002.00947.x
Subject(s) - medicine , methohexital , remifentanil , sedation , propofol , anesthesia , fentanyl , sedative , hypnotic , analgesic , surgery
Summary Background : We report the evaluation of six sedative‐hypnotic and analgesic combinations administered to children undergoing brief periods of unconscious (or deep) sedation for painful procedures. Methods : In a prospective, open‐label, randomized, controlled study of six groups of 27–30 children each, patients were randomly assigned to receive propofol or methohexital for sedation‐hypnosis, and one of three incremental doses of fentanyl or remifentanil, respectively. Results : An infusion of methohexital (10 mg·ml −1 ) combined with remifentanil (6.67 µg·ml −1 ) provided significantly shorter geometric mean times to initial emergence, to eye‐opening and to discharge, and required airway interventions that were not significantly more frequent than all groups sedated with propofol and fentanyl. Conclusions : The combination of methohexital and remifentanil appears to be a satisfactory method for unconcious sedation for short painful procedures in children.