Premium
Effects of rocuronium pretreatment on muscle enzyme levels following suxamethonium
Author(s) -
ÖZLÜ ONUR,
ERIS SENAY,
MERT ALI
Publication year - 2002
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.2002.00817.x
Subject(s) - rocuronium , medicine , myoglobin , creatine kinase , lactate dehydrogenase , saline , anesthesia , placebo , alanine aminotransferase , enzyme , endocrinology , biochemistry , intubation , pathology , chemistry , alternative medicine
Background : The effects of different time intervals between rocuronium pretreatment and suxamethonium administration on muscle‐derived enzymes and myoglobin were evaluated. Methods : Fifty‐two patients, aged 3–6 years, were allocated randomly to receive pretreatment of either rocuronium 1 min or 4 min, or a placebo, before suxamethonium. Serum creatine‐phosphokinase (CK), lactate dehydrogenase (LDH), alanine aminotransferase, aspartate aminotransferase (AST) and myoglobin concentrations were measured before treatment and at 30 min, 6 h and 24 h after suxamethonium administration. Results : Mean serum CK and myoglobin concentrations in the rocuronium groups were significantly less than in the saline group 24 h and 30 min after suxamethonium administration, respectively ( P < 0.05). There were no significant differences between the rocuronium groups. Mean LDH and AST concentrations were higher at 6 h and 24 h after suxamethonium administration compared with preadministration levels, respectively ( P < 0.05). Conclusions : We concluded that intervals of 1 min or 4 min between the rocuronium and suxamethonium administrations have the same effect on enzyme levels.