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Diffusion of ketoprofen into the cerebrospinal fluid of young children
Author(s) -
KOKKI HANNU,
KARVINEN MARKO,
JEKUNEN ANTTI
Publication year - 2002
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.2002.00808.x
Subject(s) - cerebrospinal fluid , ketoprofen , medicine , anesthesia , venous blood , pharmacology
Background : The objective was to examine whether or not ketoprofen enters the cerebrospinal fluid after a single oral dose of 1 mg·kg –1 syrup, and to find out what is the lowest plasma concentration that will achieve a measurable level in the cerebrospinal fluid. Methods : We measured ketoprofen concentrations both in plasma and cerebrospinal fluid of 10 young and healthy children (aged 9–86 months) after surgery with spinal anaesthesia. Samples of cerebrospinal fluid were collected 30 min after drug administration, at the same time as venous blood samples. A validated high‐performance liquid chromatography method with a lower limit of 0.02 μg·ml –1 was used to detect ketoprofen concentrations in cerebrospinal fluid and plasma. Results : Ketoprofen was detectable in the cerebrospinal fluid only in the child who had the highest plasma concentration, 7.4 μg·ml –1 , while at plasma concentrations 6.5 μg·ml –1 or less, cerebrospinal fluid (CSF) concentrations remained unmeasurable. The detected CSF/plasma ratio was 0.008. Conclusions : These results indicate that ketoprofen at a dose of 1 mg·kg –1 is too low to produce measurable CSF levels within 30 min of oral administration.