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Ibutilide Induced Intraatrial Wenckebach Periodicity in the Neonatal Canine Heart
Author(s) -
PICKOFF ARTHUR S.,
STOLFI ADRIENNE
Publication year - 2001
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1046/j.1460-9592.2001.01398.x
Subject(s) - ibutilide , medicine , cardiology , anesthesia , atrial fibrillation , atrial flutter
PICKOFF, A.S., et al. : Ibutilide Induced Intraatrial Wenckebach Periodicity in the Neonatal Canine Heart. In nine anesthetized canine neonates, the high right atrium was paced at progressively shorter cycle lengths while recording high right atrial electrograms and left atrial appendage monophasic action potentials before and after the administration of the new Class III agent, ibutilide. Prior to ibutilide administration, 1:1 conduction was maintained from the high right atrium to the left atrial appendage at all paced cycle lengths, down to 160 ms. Following ibutilide, a pattern of intraatrial conduction was observed in two of nine neonates at a cycle length of 160 ms that was consistent with the development of intraatrial Wenckebach periodicity. This represents one of the only demonstrations of drug induced intraatrial Wenckebach periodicity in vivo and suggests that this rarely reported form of atrial conduction block might play a role in ibutilide's clinical efficacy against atrial arrhythmias.