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Caffeine intoxication in a premature neonate
Author(s) -
Ergenekon Ebru,
Dalgiç Nazan,
Aksoy Erhan,
Koç Esin,
Atalay Yildiz
Publication year - 2001
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.2001.00753.x
Subject(s) - medicine , irritability , caffeine , metabolic acidosis , anesthesia , diuresis , acidosis , hyponatremia , water intoxication , tachycardia , menopause , kidney
Caffeine, which has a wide range between therapeutic and toxic levels, is a widely used medication for prevention and treatment of apnoea of prematurity. Despite its safety, caffeine overdose and intoxication has been previously reported in the literature. We present a 30‐day‐old 28‐week preterm newborn who was exposed to 300 mg·kg –1 caffeine base by mouth accidentally. The patient exhibited agitations, irritability, tachycardia, tachypnoea, diuresis, electrolyte abnormalities, hyperglycaemia and metabolic acidosis, for which he received supportive treatment. No seizure activity was observed. The effects of intoxication lasted for 96 h and then completely resolved.