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Retracted: Pretreatment with oral clonidine attenuates cardiovascular responses to tracheal extubation in children
Author(s) -
Fujii Yoshitaka,
Saitoh Yuhji,
Tanaka Hiroyoshi,
Toyooka Hidenori
Publication year - 2000
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.2000.00441.x
Subject(s) - medicine , clonidine , diazepam , anesthesia , blood pressure , hemodynamics , heart rate , surgery
Summary This study was designed to evaluate the effects of diazepam and clonidine orally given preoperatively on cardiovascular responses to tracheal extubation in children. Fifty children, ASA physical status I, aged 4–10 years, undergoing minor elective surgery (inguinal hernia, phimosis) received orally, in a randomized, double‐blind manner, diazepam 0.4 mg·kg −1 or clonidine 4 μg·kg −1 ( n =25 of each). These drugs were administered 105 min before an inhalational induction of anaesthesia. The same standard general anaesthetic technique was employed throughout. The maximum changes in heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were less in patients who had received clonidine than in those who had received diazepam (HR, 12 vs 24; SBP, 14 vs 26; DBP, 9 vs 16; mean, P < 0.05). In conclusion, compared to diazepam given orally, pretreatment with oral clonidine attenuates haemodynamic changes associated with tracheal extubation in children.