Premium
Tropisetron reduces postoperative vomiting in children undergoing tonsillectomy
Author(s) -
Jensen Anette B.,
Christiansen Dorte B.,
Coulthard Kingsley,
Wilkins Andrew,
Roberts Greg,
Walt Johan H.,
Rasmussen Mette
Publication year - 2000
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.2000.00401.x
Subject(s) - tropisetron , medicine , tonsillectomy , anesthesia , vomiting , placebo , antiemetic , postoperative nausea and vomiting , surgery , receptor , alternative medicine , pathology , antagonist
Summary In this patient, parent and investigator blinded, randomized, placebo‐controlled study, children undergoing tonsillectomy (mean age 6.4 years) received either intravenous placebo ( n =36) or tropisetron 0.2 mg·kg −1 up to 5 mg ( n =35) at induction of anaesthesia with halothane, nitrous oxide and oxygen. Morphine and paracetamol were given in theatre for postoperative pain. Episodes of vomiting were recorded during the first 24 h after surgery. Intravenous tropisetron was significantly ( P <0.001, chi‐squared) more effective than placebo in controlling the incidence and frequency of emesis during the first 24 h: vomiting was reduced from 89% to 46% and the mean number of vomits from 4.6 to 2.4. Minor side‐effects occurred equally in both the placebo and active groups. Intravenous tropisetron is an effective and safe antiemetic for reducing postoperative vomiting in children undergoing tonsillectomy or adenotonsillectomy.