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Paracetamol‐induced fulminant hepatic failure in a child after 5 days of therapeutic doses
Author(s) -
Morton Neil S.,
Arana Amaia
Publication year - 1999
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.1999.00423.x
Subject(s) - medicine , fulminant hepatic failure , liver failure , ingestion , hepatic encephalopathy , fulminant , lactic acidosis , encephalopathy , pediatrics , metabolic acidosis , acetaminophen , anesthesia , intensive care medicine , surgery , gastroenterology , liver transplantation , transplantation , cirrhosis
Summary We report the case of a two and a half year‐old girl who developed fulminant hepatic failure following 5 days of regular oral ingestion of paracetamol, approximately 90 mg·kg −1 ·day −1 . She presented with the typical findings of hepatomegaly, encephalopathy, high ammonia levels, high transaminases, hypoglycaemia and lactic acidosis. After stabilization, she was transferred to a specialist paediatric liver failure unit and fortunately she made a full recovery with intensive medical management.