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Retracted : Prophylactic therapy with granisetron in the prevention of vomiting after paediatric surgery. A randomized, double‐blind comparison with droperidol and metoclopramide
Author(s) -
FUJII YOSHITAKA,
TANAKA HIROYOSHI
Publication year - 1998
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.1998.00761.x
Subject(s) - medicine , droperidol , antiemetic , metoclopramide , granisetron , anesthesia , placebo , vomiting , nausea , postoperative nausea and vomiting , surgery , alternative medicine , pathology
The antiemetic efficacy of droperidol, metoclopramide and granisetron was compared with placebo in the reduction of vomiting after paediatric surgery (the extremities; inguinal hernia; and phimosis) during general inhalational anaesthesia. One hundred children, ASA physical status I, 4–10 years of age, were enrolled in a prospectively, randomized, double‐blind investigation and assigned to one of four treatment regimens: placebo (saline, n =25), droperidol (50 μg·kg 1 , n =25), metoclopramide (0.25 mg·kg‐ 1 , n =25) or granisetron (40 μg·kg ‐1 , n =25). These drugs were administered intravenously (iv) after inhalation induction of anaesthesia. A complete response, defined as no emesis and no need for another rescue antiemetic during the first 24 h after anaesthesia, occurred in 60%, 76%, 68% and 88% of patients who had received placebo, droperidol, metoclopramide and granisetron, respectively ( P <0.05; overall Fisher's exact probability test). The incidence of adverse events postoperatively was not different among the treatment groups. In conclusion, granisetron 40 μg·kg ‐1 is a better antiemetic than droperidol and metoclopramide when compared to placebo for the prevention of postoperative emesis in children.