Premium
Respiratory function in children during recovery from neuromuscular blockade
Author(s) -
WITHINGTON DAVINIA,
DAVIS G.,
VALLINIS PETER,
DEL SONNO PINA,
BEVAN JOAN
Publication year - 1998
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.1998.00711.x
Subject(s) - medicine , neuromuscular blockade , neuromuscular transmission , neuromuscular monitoring , anesthesia , transpulmonary pressure , respiratory system , ventilation (architecture) , tidal volume , respiratory minute volume , functional residual capacity , artificial ventilation , paralysis , lung volumes , respiratory failure , mechanical ventilation , respiratory disease , lung , surgery , mechanical engineering , engineering
Residual neuromuscular blockade is a major risk factor for respiratory insufficiency. We examined the relationship between neuromuscular and respiratory function in 18 ASA I or II children aged 2–4 years. Lung function was measured by pneumotachography and transpulmonary pressure, neuromuscular transmission by first twitch response ratio (T1:T1) and train‐of‐four ratio (TOFR), before and at specific points in recovery from vecuronium paralysis. The tidal volume was directly related to maximal inspiratory pressure at occlusion ( P I occ), P <0.001, whereas the minute ventilation (V E ) was related to the respiratory drive (P0.1), P <0.001. The best predictors of minute ventilation were the P0.1 ( r =0.57), and the TOFR ( r =0.62). P I occ and P0.1 correlated closely ( r =0.889, P =0.002) but TOFR and T1:T1 did not correlate with either. Our results show that the occlusion pressure measurements, P0.1 and P I occ, were good predictors of both V E ·kg −1 and respiratory work.