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A timed reexpansion inspiratory manoeuvre (TRIM) for treating oxyhaemoglobin desaturation in children following a period of apnoea—studies in an animal model
Author(s) -
Vanessa M. McDonald,
Van der Walt,
Parnis
Publication year - 1998
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.1998.00274.x
Subject(s) - medicine , anesthesia , ventilation (architecture) , trim , nitrous oxide , oxygen saturation , airway , respiratory rate , oxygen , heart rate , blood pressure , mechanical engineering , chemistry , organic chemistry , computer science , engineering , operating system
Our clinical experience has shown that the use of a constant distending airway pressure of 30 cm water for 10 s, termed a timed reexpansion inspiratory manoeuvre (TRIM), is often successful in correcting oxyhaemoglobin desaturation in anaesthetized children. The aim of this study was to assess the efficacy of TRIM in lambs. Following a standard relaxant anaesthetic, ventilation was stopped and oxyhaemoglobin saturation allowed to fall to 70% and the time taken to return to baseline was compared between three groups. The median time was 42.5 s when ventilation was restarted with 33% oxygen in nitrous oxide (33% group), 30 s when ventilation was restarted with 100% oxygen (100% group) and 22.5 s with a TRIM before restarting ventilation with 33% oxygen in nitrous oxide (TRIM group). The correction of desaturation was more rapid in the TRIM group compared with the 33% group ( P <0.004) and the 100% group ( P <0.003). Oxyhaemoglobin desaturation due to apnoea in anaesthetized lambs is more effectively treated with a TRIM than by increasing the inspired oxygen fraction.