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Oral midazolam compared with diazepam‐droperidol and trimeprazine as premedicants in children
Author(s) -
PATEL D,
MEAKIN G
Publication year - 1997
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1046/j.1460-9592.1997.d01-88.x
Subject(s) - droperidol , midazolam , diazepam , medicine , anesthesia , premedication , benzodiazepine , sedation , fentanyl , receptor
Ninety children were assigned randomly to one of three groups for premedication with oral midazolam 0.5 mg·kg −1 , diazepam 0.25 mg·kg −1 with droperidol 0.25 mg·kg −1 , or trimeprazine 2 mg·kg −1 . On arrival at the anaesthetic room, anxiolysis was satisfactory in 26 out of 29 (90%) children who received midazolam compared with 23 out of 29 (79%) who received diazepam‐droperidol and 18 out of 29 (62%) who received trimeprazine ( P <0.05); at induction of anaesthesia these proportions were 24 out of 29 (83%), 16 out of 29 (55%) and 11 out of 29 (40%) respectively ( P <0.001). When individual groups were compared, anxiolysis was significantly greater in the midazolam group compared with the trimeprazine group on arrival in the anaesthetic room ( P <0.05) and significantly greater in the midazolam group than in either the diazepam‐droperidol or the trimeprazine groups at induction of anaesthesia ( P <0.05 and P <0.001 respectively). There were no significant differences in times to early recovery between the groups (25.4, 24.4 and 28.5 min). Analysis of behavioural questionnaires completed two weeks after hospitalization showed a trend towards fewer postoperative behavioural disturbances in children who received midazolam or diazepam‐droperidol compared with trimeprazine (47 and 44% vs 75%); when the results for the benzodiazepine‐containing premedicants were combined, the difference between these groups and trimeprazine was statistically significant ( P <0.05).