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Conditional involvement of striatal serotonin 3 receptors in the control of in vivo dopamine outflow in the rat striatum
Author(s) -
Porras Grégory,
De Deurwaerdère Philippe,
Moison Delphine,
Spampinato Umberto
Publication year - 2003
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.2003.02512.x
Subject(s) - chemistry , dopamine , pharmacology , microdialysis , neurochemical , amphetamine , striatum , ondansetron , serotonin , ritanserin , raclopride , 5 ht receptor , endocrinology , medicine , receptor , biochemistry , nausea
Serotonin 3 (5‐HT 3 ) receptors can affect motor control through an interaction with the nigrostriatal dopamine (DA) neurons, but the neurochemical basis for this interaction remains controversial. In this study, using in vivo microdialysis, we assessed the hypothesis that 5‐HT 3 receptor‐dependent control of striatal DA release is conditioned by the degree of DA and/or 5‐HT neuron activity and the means of DA release (impulse‐dependent vs. impulse‐independent). The different DA‐releasing effects of morphine (1 and 10 mg/kg), haloperidol (0.01 mg/kg), amphetamine (1 and 2.5 mg/kg), and cocaine (10 and 20 mg/kg) were studied in the striatum of freely moving rats administered selective 5‐HT 3 antagonists ondansetron (0.1 mg/kg) or MDL 72222 (0.03 mg/kg). Neither of the 5‐HT 3 antagonists modified basal DA release by itself. Pretreatment with ondansetron or MDL 72222 reduced the increase in striatal DA release induced by 10 mg/kg morphine but not by 1 mg/kg morphine, haloperidol, amphetamine or cocaine. The effect of 10 mg/kg morphine was also prevented by intrastriatal ondansetron (1 µ m ) administration. Reverse dialysis with ondansetron also reduced the increase in DA release induced by the combination of haloperidol and the 5‐HT reuptake inhibitor citalopram (1 mg/kg). Considering the different DA and 5‐HT‐releasing properties of the drugs used, our results demonstrate that striatal 5‐HT 3 receptors control selectively the depolarization‐dependent exocytosis of DA only when central DA and 5‐HT tones are increased concomitantly.