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Mice lacking the adenosine A 1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate
Author(s) -
GiménezLlort Lydia,
FernándezTeruel Alberto,
Escorihuela Rosa Maria,
Fredholm Bertil B.,
Tobeña Adolf,
Pekny Milos,
Johansson Björn
Publication year - 2002
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.2002.02122.x
Subject(s) - open field , elevated plus maze , adenosine , anxiety , psychology , morris water navigation task , receptor , medicine , neuroscience , developmental psychology , endocrinology , hippocampus , psychiatry
Behavioural assessment of mice lacking adenosine A 1 receptors (A 1 Rs) showed reduced activity in some phases of the light–dark cycle, reduced exploratory behaviour in the open‐field and in the hole‐board, increased anxiety in the plus maze and dark‐light box and increased aggressiveness in the resident‐intruder test. No differences were found in spatial reference and working memory in several Morris water maze tasks. Both mutant mice had reduced muscle strength and survival rate. These results confirm the involvement of adenosine in motor activity, exploratory behaviour, anxiety and aggressiveness. A 1 Rs also appear to play a critical role in ageing‐related deterioration.