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Layer‐specific immunocytochemical localization of GABA B R1a and GABA B R1b receptors in the rat piriform cortex
Author(s) -
Princivalle Alessandra,
Spreafico Roberto,
Bowery Norman,
De Curtis Marco
Publication year - 2000
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.2000.01060.x
Subject(s) - piriform cortex , gabaergic , inhibitory postsynaptic potential , neuroscience , receptor , biology , neurotransmitter , gamma aminobutyric acid , neurotransmission , postsynaptic potential , microbiology and biotechnology , chemistry , biophysics , central nervous system , biochemistry
A peculiar, layer‐segregated immunoreactive distribution of GABA B R1a and GABA B R1b receptor antibodies is present in the piriform cortex of adult rats. The GABA B R1a antibody selectively marked the neuropile in layer Ia, where afferent olfactory fibres and intrinsic GABAergic (γ‐aminobutyric acid) axons terminate on the distal apical dendrites of pyramidal neurons. The GABA B R1b antibody was detected in the soma and the large basal dendrites of layer II and III neurons. The pattern of distribution observed supports the hypothesis that (presynaptic) GABA B R1a receptors in the superficial molecular layer modulate neurotransmitter release in a feedforward synaptic circuit, whereas GABA B R1b (postsynaptic) receptors mediate feedback inhibitory potentials on principal cells.