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Coupled intra‐ and extracellular Ca 2+ dynamics in recurrent seizure‐like events
Author(s) -
Szilágyi Nóra,
Kovács Richárd,
Kardos Julianna
Publication year - 2000
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.2000.00284.x
Subject(s) - extracellular , attractor , hippocampal formation , oscillation (cell signaling) , intracellular , local field potential , physics , cytosol , biophysics , coupling (piping) , dynamics (music) , phase space , neuroscience , chemistry , nuclear magnetic resonance , biology , mathematics , biochemistry , materials science , mathematical analysis , quantum mechanics , acoustics , metallurgy , enzyme
We considered the evolution of Ca 2+ oscillation dynamics in recurrent seizure‐like events. Dynamic system behaviour was characterized in the state space reconstructed from intra‐ and extracellular [Ca 2+ ] fluctuations simultaneously measured in cultured rat hippocampal slices under low‐[Mg 2+ ] conditions. When associated in the seizure‐like event, these fluctuations occurred on a restricted set, the attractor, embedded in the full state space with less than five degrees of freedom. Instantaneous relative phase differences indicated field potential‐driven phase jumps locked onto seizure‐like events. To account for recurrent dynamics, calculations were performed on different extensions of a model for Ca 2+ oscillation. These identified bidirectional, asymmetrical coupling of extracellular with intracellular (cytosolic, Ca 2+ store, mitochondrial) Ca 2+ dynamics as critical in its development.